Endocrine Abstracts

Developmental programming of insulin resistance in the offspring of diabetic mothers have contributed significantly to the increased prevalence of type 2 diabetes mellitus and other metabolic disorders in the general population. Vitamin D has been reported to improve glucose metabolism, however its potential in reversing glucose intolerance programmed in the offspring of diabetic mothers has not been fully elucidated. The study therefore aimed to investigate the effect of vita...

Polycystic ovarian syndrome (PCOS) is a common endocrine and gynaecological disorder, occurring in 5% to 20% women of reproductive age. It is characterized by hyperandogenism, ovulatory dysfunction and polycystic ovaries. Impaired hypothalamic-pituitary-ovarian axis, insulin resistance and oxidative stress are identified causal mechanisms of PCOS. Vernonia amydalina(VA) leaf is a medicinal plant containing bioactive phytochemicals known to improve insulin sensitivity....

Polycystic ovary syndrome (PCOS) is an endocrine disorder that is common among women in their reproductive ages. This condition is associated with insulin resistance, oxidative stress, hormonal imbalance, and inflammation. Various drugs are used in treating this disorder but with side effects, hence the need for an alternative treatment with minimal side effects. This study was aimed at investigating the effect of methanol extract of Vernonia amygdalina on the reprodu...